Organotrifluoroborate enhances tumor targeting of fibroblast activation protein inhibitors for targeted radionuclide therapy
We designed a new radioligand named FT-FAPI which means fast-treatment FAPI. This compound is composed of 3 parts: 18F can be facilely labeled in BF3 via isotopic exchange, DOTA is the gold standard chelator for most radiometals, and finally, the FAPI-04 for FAP targeting. We hope that FT-FAPI can realize radiotheranostics in a single molecule.