Covalent bonding radiopharmaceuticals have been developed in some studies, but they all have obvious deficiencies, mainly due to their high lipophilicity and non-specific covalent bonding. These fatal defects make them completely unable to be used for targeted radionuclide therapy.
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We designed a new radioligand named FT-FAPI which means fast-treatment FAPI. This compound is composed of 3 parts: 18F can be facilely labeled in BF3 via isotopic exchange, DOTA is the gold standard chelator for most radiometals, and finally, the FAPI-04 for FAP targeting. We hope that FT-FAPI can realize radiotheranostics in a single molecule.
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